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Zapizolam (D 13129) is a pyridodiazepine drug, which is a benzodiazepine analog of pyridotriazolodiazepine group. It has sedative and anxiolytic effects similar to those produced by benzodiazepine derivatives and has been sold illicitly as a designer drug.

What is Zapizolam?

Zapizolam Risk of fatal intoxication increases if benzodiazepines or benzodiazepine analogues, such as pyridodiazepine, are combined with other CNS depressants such as opioids or alcohol. It is common to addicts use benzodiazepines to enhance the euphoria the effect of opioids as well as to relieve unwanted symptoms in drug abuse.

Effects of Pyridodiazepine

Zapizolam powder combination between opioids and other drug groups was very common, and that the combination opioid and benzodiazepine were most frequent. A well-known risk in use of benzodiazepines is also the development of tolerance and dependence.

How Strong is Zapizolam?

Zapizolam Benzodiazepines (BZDs) act as positive allosteric modulators on the gamma-aminobutyric acid (GABA)_A receptor [1]. GABA represents the main inhibitor neurotransmitter in the brain and plays an important role in modulating the activity of many neurons, including those in the amygdala and prefrontal cortex [1].

Where to get Strongest Benzodiazepines?

Zapizolam GABA_A receptor is a ligand-gated chloride-selective ion channel build-up of five subunits: two α, two ß (the binding site for endogenous neurotransmitter) and one γ. BZDs bind to the pocket created by α and γ subunits and induce a conformational change in the GABA_A receptor.

What is D-13129?

12-chloro-9-(2-chlorophenyl)-2,4,5,8,11-pentazatricyclo[8.4.0.02,6]tetradeca-1(10),3,5,8,11,13-hexaene

8-chloro-6-(2-chlorophenyl)-4H-pyrido[2,3-f][1,2,4]triazolo[4,3-a][1,4]diazepine