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Temazepam is a benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreases neuronal excitability.

What is Temazepam?

Temazepam has become one of the most frequently prescribed medications internationally and sees millions of prescriptions every year. Unfortunately, however, given its frequent use and the inherent nature of its pharmacological effects, temazepamum – like many other benzodiazepines – possesses a high potential for misuse and is genuinely capable of developing drug tolerance, physical dependence, and addiction in users.

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Temazepam is use as treatment for insomnia was accepted and approved later on. In particular, before temazepam saw regular prescription use in civilians it was – and still is – employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to obtain the necessary rest required for medical recovery or scheduled maneuvers and operations.

How to use Hydroxydiazepam?

Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action. Although the chemical synthesis of temazepamum was established by 1965, mainstream contemporary use of the medication did not occur until it’s legitimate use as treatment for insomnia was accepted and approved later on.

How long does last in the body Temazepamum?

Temazepam has very good bioavailability, with almost 100% being absorbed following being taken by mouth. The drug is metabolized through conjugation and demethylation prior to excretion. Most of the drug is excreted in the urine, with about 20% appearing in the faces. The major metabolite was the O-conjugate of temazepamum (90%); the O-conjugate of N-desmethyl Temazepam was a minor metabolite (7%).