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Flualprazolam is a novel depressant substance of the benzodiazepine class. Flualprazolam is chemically related to alprazolam (Xanax), differing by the addition of a fluorine atom, and is reported to produce similar psychoactive effects. Flualprazolam appears to have first become available for sale on the online research chemical market in 2017 

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Users should note that the sudden discontinuation of benzodiazepines can be dangerous or even life-threatening for individuals for heavy or long-term users. As a result, individuals who are physically dependent on this substance are advised to taper their dose by gradually lowering the amount taken each day over a prolonged period instead of stopping use abruptly. It is strongly advised to use harm reduction practices when using this substance. 

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Flualprazolam is a substance of the benzodiazepine class. Benzodiazepines contain a benzene ring fused to a diazepine ring, which is a seven membered ring with the two nitrogen constituents located at R1 and R4. The benzyl ring of flualprazolam is substituted at R8 with a chlorine group.  

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 Further, the diazepine ring is bonded at R5 to a phenyl ring. The only difference to alprazolam is a flourine group located at R2′. Flualprazolam also contains a 1-methylated triazole ring fused to and incorporating R1 and R2 of its diazepine ring. It belongs to a class of benzodiazepines containing this fused triazole ring, called triazolobenzodiazepines, distinguished by the suffix “–zolam“. 

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Flualprazolam likely has a low toxicity relative to dose. However, it is potentially lethal when mixed with depressants like alcohol or opioids. It is strongly recommended that one use harm reduction practices when using this substance. 

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If choosing to combine these substances, one should strictly limit themselves to a pre-set schedule of dosing only a certain amount per hour until a maximum threshold has been reached.

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