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Piperonyl Methyl Ketone or 3,4-Methylenedioxyphenylpropan-2-one(MDP2P or PMK) is a chemical compound  consisting of a phenylacetone moiety substituted with a methylenedioxy functional group. It is commonly  synthesized from either safrole (which, for comparison, is 3-[3,4-(methylenedioxy)phenyl]-2-propene) or its isomer isosafrole via oxidation using the Wacker oxidation or peroxyacid oxidation methods. Piperony Methy Ketone (MDP2P) is unstable at room temperature and must be kept in the freezer in order to be preserved properly.

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Piperony Methy Ketone (MDP2P) is a precursor in the chemical synthesis of the methylenedioxyphenethylamine (MDA)  class  of compounds, the classic example of which is 3,4-methylenedioxy-N-methylamphetamine (MDMA), and is also an intermediate between the MDA family and their slightly more distant precursor safrole or isosafrole.

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On account of its relation to the MDA chemical class, Piperony Methy Ketone (MDP2P), as well as safrole and isosafrole, are in the United States (U.S.) Drug Enforcement Administration (DEA) List I of Chemicals of the Controlled Substances Act (CSA) via the Chemical Diversion and Trafficking Act (CDTA). It is also considered a category 1 precursor in the European Union.

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Other Names; MDP2P; Piperonyl methyl ketone; 3,4-Methylenedioxyphenylacetone; 3,4-Methylenedioxyphenyl-2-propanone; PMK Oil; CAS Number 4676-39-5; Piperonylmethylketone; 3,4-Methylenedioxybenzyl methyl ketone;1-(1,3-Benzodioxol-5-yl)acetone; 5-Acetonyl-1,3-benzodioxole; PVI-2