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Precursor chemicals such as BMK Methyl Glycidate are essential for the manufacturing of ATS. The availability of precursors can have an important impact on the market and production methods.4 To circumvent international control measures, clandestine amphetamine producers increasingly switch to pre‐precursors that, themselves, are not subject to international control measures and can be easily converted to BMK Methyl Glycidate in the producing countries.  

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Another “advantage” of the pre‐precursors from the producers’ point of view is their completely different appearance when compared to BMK. BMK Methyl Glycidate is a liquid with a characteristic smell but most of the pre‐precursor compounds observed as of yet are crystalline solids, most of which are colorless, and possess different odor profiles. They are often trafficked using various false declarations. One of the first examples of this kind of BMK pre‐precursor was the bisulfite adduct of BMK as reported in the Netherlands.2 New pre‐precursors can emerge quite quickly, as evidenced by the appearance of α‐phenylacetoacetonitrile (APAAN) in recent years.  

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This was illustrated in our recent publication which showed that the occurrence of route‐specific APAAN markers in amphetamine samples seized in Germany and the Netherlands changed from 0% in 2009 up to almost 100% in 2014.5 Due to the increased use of APAAN for the clandestine production of amphetamine, this chemical was placed under control in 2013 in Europe and under international control in 2014.6 The control measure appears to have prompted the producers to switch to other alternatives like α‐phenylacetoacetamide (APAA) and recently also glycidic acid derivatives and methyl α‐phenylacetoacetate (MAPA).4  

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The chemical structures of these pre‐precursors are given in Figure 1. The rise of such new pre‐precursors adds even more complexity to a drug market that is already becoming more sophisticated.1 The trend to use pre‐precursors other than APAAN is reflected by a decrease in seized APAAN in Europe going from 11 tons in 2014, to 1.5 tons in 2015 down to 600 kg in 2016.7  

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Other Names: CAS 80532-66-7; BMK Powder; Methyl Ester; BMK Glycidate; Benzeneacetic acid; methyl-2-methyl-3-phenylglycidate