Nitrazolam is a triazolobenzodiazepine (TBZD), which are benzodiazepine (BZD) derivatives, that has been sold online as a designer drug. Nitrazolam has been used as an example compound to demonstrate the microscale synthesis of reference materials utilizing polymer‐supported reagents.
What is Nitrazolam?
Nitrazolam has been classified as a Class C drug by the May 2017 amendment to The Misuse of Drugs Act 1971 along with several other designer benzodiazepine drugs. It is closely related to Clonazolam or Flunitrazolam, only differing by the removal of a Chlorine or Fluorine group respectively at the benzene ring.
How Strong is Triazolobenzodiazepine?
A study in mice indicated that nitrazolam can be several times more potent than diazepam as an antagonist of electroshock-induced tonic-extensor convulsions but less potent than diazepam at preventing the righting reflex.
Benzodiazepines (BZDs) act as positive allosteric modulators on the gamma-aminobutyric acid (GABA)A receptor . GABA represents the main inhibitor neurotransmitter in the brain and plays an important role in modulating the activity of many neurons, including those in the amygdala and prefrontal cortex .
What is Effect of Nitrazolam?
The GABAA receptor is a ligand-gated chloride-selective ion channel build-up of five subunits: two α, two ß (the binding site for endogenous neurotransmitter) and one γ. BZDs bind to the pocket created by α and γ subunits and induce a conformational change in the GABAA receptor.