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Gamma-Hydroxybutyrate (GHB) is found naturally – in small amounts – in human cells. It is a neurotransmitter and also affects other neurotransmitters, including GABA (gamma-aminobutyric acid) and dopamine. At low doses, GHB inhibits dopamine release, but at high doses, it promotes dopamine release. It also increases serotonin turnover and inhibits the release of norepinephrine.
Gamma-Hydroxybutyrate (GHB) is found naturally – in small amounts – in human cells. It is a neurotransmitter and also affects other neurotransmitters, including GABA (gamma-aminobutyricacid) and dopamine. At low doses, GHB inhibits dopamine release, but at high doses, it promotes dopamine release. It also increases serotonin turnover and inhibits the release of norepinephrine.
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Gamma-Hydroxybutyrate was developed in the early 1960s for potential use as an anesthetic agent. Due to its lack of analgesic qualities and some disturbing side effects, including seizures, it is now rarely used in anesthesiology. It also used to treat narcolepsy and sometimes in recovery from alcoholism.
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In the 1990s, Gamma-Hydroxybutyrate began to be sold in health food stores as a remedy for insomnia and for its growth-hormone-enhancing properties, which made it popular among bodybuilders. But due to a series of poisonings, GHB was withdrawn from the market and banned in 1991. In March 2000, it was classified as a Schedule 1 controlled substance. Perhaps its most common use today is as a “club drug,” which users take in small doses to reduce their inhibitions and engender a sense of wellbeing and confidence. It has even been reported to have aphrodisiac qualities.
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In larger doses, however, Gamma-Hydroxybutyrate can induce sleep or unconsciousness and inhibit the formation of memories. Because of this, it is also used by some as a “date rape” drug. It is usually sold in a liquid form, making it easy to slip into a drink. It has even been used as a method of murder by a serial killer in England who preyed on gay men he met online, secretly overdosed with GHB, and then raped.
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The powder form of GHB is not nearly as common as the liquid form, but the method of use is almost the same. As a central nervous system depressant, it can be lethal when taken in conjunction with alcohol or other depressants. As with many street drugs, the composition of Gamma-Hydroxybutyrate will vary. Since it is sold in various concentrations, there is no way users can know just how strong a dose may be, which increases the risk of overdose.
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