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Gamma-Butyrolactone, or GBL, is a precursor to GHB that has a range of industrial and commercial uses. It serves as an intermediate when making pyrrolidones, industrial chemicals that are in wide use. Because of its significant properties as a solvent, it is a common solvent found in paint strippers, nail polish removers, and stain removers. 

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Because of its chemical similarity, Gamma-Butyrolactone is a “prodrug” of GHB, meaning it is converted into GHB in the body, and its effects are identical. However, it is two to three times as powerful as GHB, and its effects are felt faster. This makes it a far greater risk for overdose than GHB, but both drugs can have serious downsides from overconsumption, up to and including coma and death. The drug was linked to almost 40 overdoses at a single music event in Melbourne, Australia, in 2017. 

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According to the UK’s Independent Scientific Committee on Drugs, accidental overdose is far too easy with GHB and GBL: “An extra half-millilitre of Gamma-Butyrolactone or half-gram of GHB on top of a moderate dose can make you fall into a deep sleep where you could potentially choke to death on your own vomit.” In one year, Sweden had the same number of fatal overdoses from GHB as they did from heroin.  

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Because of its memory-inhibiting qualities, the danger of losing track of how much someone has taken (especially since it is often delivered via a drink) is much higher, leading to a greater chance of accidental overdose. One sip too many can often mean the difference between euphoria and unconsciousness. Gamma-Butyrolactone can be easily synthesized into GHB simply by changing the pH level by adding an alkali such sodium hydroxide. Recipes for this process are widely available on the Internet, and some sites will not only identify the materials needed, but sell them, too. 

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However, converting GBL into GHB is redundant because the body will rapidly metabolize the GBL into GHB after ingestion. Once that occurs, the effects and risks of Gamma-Butyrolactone are identical to GHB. But because the onset of action of GBL is faster, its potency much greater, and the duration of action longer, GBL may have a greater potential for misuse than GHB. 

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Other Names; GBL; (2(3H)-Furanone Dihydro; 3-Hydroxybutyric Acid Lactone; 4-Butanolide; 4-Butyrolactone; 4-Hydroxybutanoic Acid Lactone; Acide 4-Hydroxybutanoïque Lactone; Butyrolactone; Butyrolactone Gamma; Dihydro-2(3H)-Furanone; Gamma Butirolactona; Gamma Hydroxybutyric Acid Lactone; Tetrahydro-2-Furanone; Y-Butyrolacton; Oxolan-2-one

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Butyrolactone (GBL) is a hygroscopic colorless, water-miscible liquid with a weak characteristic odor. It is the simplest 4-carbon lactone. It is mainly used as an intermediate in the production of other chemicals, e.g. methyl-2-pyrrolidone. In humans GBL acts as a prodrug for ?-hydroxybutyric acid (G-H-B), and it is used as a recreational intoxicant with effects similar to barbiturates.

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