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Camfetamine has been rediscovered as recreational drug in 2011. Very little information is still available in the scientific literature on its nature and potential health risks. Methods. Data in scientific literature were integrated with a multilingual qualitative assessment of a range of online resources over the period of 32 months (May 2011–January 2014). N-Methyl-3-phenyl-norbornan-2-amine (Camfetamine) may act as an indirect dopaminergic agonist in the central nervous system and may have mild-moderate opioid activity too.

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There are no current epidemiological data about recreational use of Camfetamine; our research shows that it is indeed used especially by individuals with a history of recreational polydrug misuse. It facilitates mental alertness, induces relaxation, and, unlike many other stimulants, seems not to be associated with severe physical effects. Valid causes for concern issued in our research may be Camfetamine intravenous or intramuscular administration as well as its use in conjunction with other psychoactive substances. Conclusions.4 It is here highlighted that more large-scale studies need to be carried out to confirm and better describe both the extent of Camfetamine misuse and possible psychotropic/adverse effects.

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The literature on Camfetamine was searched in three databases: PsycINFO, PubMed, and Medscape. Keywords used to carry out the database searches included the following: “N-methyl-3-phenyl-norbornan-2-amine,” “Camfetamyne,” and “N-methyl-3-phenylbicyclo[2.2.1]heptan-2-amine.” This apparent structural simplicity belies the vast number of novel psychoactive substances and their corresponding and varied psychoactive effects that can be produced from modifications to the phenylethylamine backbone [13]. Camfetamine (N-methyl-3-phenylnorbornan-2-amine) and its N-ethyl analogue Fencamfamine are heterocyclic amphetamine derivatives14.

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Thus, nowadays very little is known about the pharmacology of Camfetamine but it may be expected to have similar properties to its N-ethyl analogue Fencamfamine (FCF) [10]. However, Camfetamyne is potentially less lipophilic (calculated log D (pH 7.4) = 0,01 whereas the value Fencamfamine is 0,31) and this may result in lower bioavailability across the blood brain barrier [10]. Fencamfamine (FCF) is a psychostimulant that has complex effects in the central nervous system. Regarding acute effects, some studies suggest that FCF releases dopamine (DA) from both α-methyl-p-tyrosine and reserpine pools at dopaminergic cerebral nerve terminals [16].

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Other names: N-methyl-3-phenyl-norbornan-2-amine Online, Fencamfamine Online, CAS 92499-19-9